Bruno Sacchetto Paulo, PhD

As a researcher in the Eustáquio Lab, I explore the metabolic potential of bacteria to uncover novel natural products. I’m particularly interested in genetic engineering, pathway refactoring, and biocatalysis to better understand how microbes build complex molecules.

With a background in biotechnology, I’ve worked across everything from plasmid design to metabolite profiling by LC-MS. I’m passionate about using biosynthetic logic to solve tough challenges in microbial metabolism.

Outside the lab, I enjoy good coffee and video games.

1. Bruno S. Paulo, Michael Recchia, Lee S, Claire Fergusson, Sean Romanowski, Antonio

   Hernandez, et al. Discovery of megapolipeptins by genome mining of a Burkholderiales bacteria

   collection. Chem. Sci. 2024, 15, 16567.

2. Bruno S. Paulo, Renata Sigrist, Célio F. F. Angolini, Luciana G. De Oliveira. New

   cyclodepsipeptide derivatives revealed by genome mining and molecular networking.

   Chemistryselect. 2019, 4, 7785.

3. Claire H. Fergusson, Julia Saulog, Bruno S. Paulo, Darryl M. Wilson, Dennis Y. Liu, Nicholas J.

   Morehouse, Samantha Waterworth, John Barkei, Christopher A. Gray, Jason C. Kwan, Alessandra

   mining, isotopic labeling, and untargeted metabolomics. Chem. Sci., 2024,15, 8089-8096.4

   Eustaquio, Roger G. Linington. Discovery of a lagriamide polyketide by integrated genome

4. Sean B. Romanowski, Sanghoon Lee, Sylvia Kunakom, Bruno S. Paulo, Michael J. J. Recchia,

   Dennis Y. Liu, Hannah Cavanagh, Roger G. Linington, Alessandra S. Eustáquio. Identification of

   the lipodepsipeptide selethramide encoded in a giant nonribosomal peptide synthetase from a

   Burkholderia. Proc. Natl. Acad. Sci., 2023, 120, e2304668120.

Ph.D. Organic chemistry (State University of Campinas – UNICAMP)
M.S. Organic chemistry (State University of Campinas – UNICAMP)
B.A. Chemistry (Federal University of São Carlos – UFScar)